TEHRAN, June 14, 2025 (BSS/AFP) - Iran struck Israel early Saturday with barrages of missiles after a massive onslaught targeted the Islamic republic's nuclear and military facilities, and killed several top generals.

Air raid sirens and explosions rang out across Israel overnight, with its military calling on residents to take refuge in bomb shelters Saturday morning.

The Israeli military said dozens of missiles -- some intercepted -- had been fired in the latest salvos from Iran.

Smoke was billowing above skyscrapers in downtown Tel Aviv, an AFP journalist reported, as Iran's Revolutionary Guard said it had attacked dozens of targets in Israel.

Israel's firefighting service said its teams were responding to the aftermath of Iranian missile strikes, including working to rescue people trapped in a high-rise building.

Rescuers said 34 people had been wounded in the Gush Dan area, including a woman who later died of her injuries, according to Israeli media reports.

Resident Chen Gabizon told AFP he ran to an underground shelter after receiving an alert notification.

"After a few minutes, we just heard a very big explosion, everything was shaking, smoke, dust, everything was all over the place," he said.

In Iran's capital Tehran early Saturday, fire and heavy smoke billowed from Mehrabad airport, an AFP journalist said, as local media reported a blast in the area.

Iran said earlier it had activated its air-defence system and explosions could be heard across the capital.

Dozens of people took to the streets of Tehran overnight to cheer their country's military response, with some waving national flags and chanting anti-Israel slogans.

Iran's ambassador to the UN said Friday that 78 people had been killed and 320 wounded in the first wave of strikes by Israel.

After a day of back-and-forth bombardments, UN chief Antonio Guterres called for the two nations to cease fire.

"Enough escalation. Time to stop. Peace and diplomacy must prevail," he wrote on X late Friday.

- Calls for dialogue -

US officials said they were helping Israel defend against the missile attacks, even as Washington insisted it had nothing to do with Israel's strikes on Iran.

US President Donald Trump agreed on a call with UK Prime Minister Keir Starmer that "dialogue and diplomacy" were needed to calm the crisis, Starmer's office said.

Trump also spoke with Israel's Prime Minister Benjamin Netanyahu Friday, US officials said, without elaborating.

Iran's missile salvo came hours after Israel said its widespread air raids had killed several top Iranian generals, including most of the senior leadership of the Revolutionary Guards' air force.

It had launched several rounds of strikes that hit about 200 targets including nuclear facilities and air bases.

Iran's supreme leader Ayatollah Ali Khamenei vowed to bring Israel "to ruin" during a televised address.

In Israel, Netanyahu issued a statement calling on the Iranian public to unite against their own government. But he also warned more attacks were coming.

"In the past 24 hours, we have taken out top military commanders, senior nuclear scientists, the Islamic regime's most significant enrichment facility and a large portion of its ballistic missile arsenal," Netanyahu said.

While stressing that it was not involved in the Israeli attacks, the United States warned Iran not to attack its personnel or interests.

Tehran nevertheless said Washington would be "responsible for consequences".

- Commanders killed -

The strikes killed Iran's highest-ranking military officer, armed forces chief of staff Mohammad Bagheri, and the head of the Revolutionary Guards, Hossein Salami, Iranian media reported.

Khamenei swiftly appointed new commanders to replace those killed.

"The senior chain of command of the air force of the Islamic Revolutionary Guards Corps had assembled in an underground command centre to prepare for an attack on the State of Israel," the Israeli military said, adding that its attacks had killed most of them.

Iran confirmed that the Guards' aerospace commander had been killed, along with "a group of brave and dedicated fighters".

AFP images showed a gaping hole in the side of a Tehran residential building that appeared to have sustained a targeted strike.

Tasnim news agency said six nuclear scientists were among the dead.

Oil prices surged while stocks sank on the Israeli strikes.

- Radiation 'unchanged' in Natanz area -

The conflict raised questions as to whether Sunday's sixth round of talks planned between the United States and Iran to seek a deal on Iran's nuclear programme would go ahead in Oman.

After the first wave of strikes on Friday, Trump urged Iran to "make a deal", adding that Washington was "hoping to get back to the negotiating table".

Iran confirmed that above-ground sections of the Natanz enrichment plant had been destroyed, but the International Atomic Energy Agency (IAEA) said radiation levels outside the site "remained unchanged".

"Most of the damage is on the surface level," said the Atomic Energy Organisation of Iran's spokesman Behrouz Kamalvandi.

Iran said there was only limited damage to the Fordo and Isfahan nuclear sites.

The United States and other Western governments have repeatedly accused Iran of seeking a nuclear weapon, an ambition it has consistently denied.

Netanyahu said Israeli intelligence had concluded that Iran was approaching the "point of no return" on its nuclear programme.

Israel had called for global action after the IAEA accused Iran on Thursday of non-compliance with its obligations.

Iran currently enriches uranium to 60 percent, far above the 3.67-percent limit set by a largely moribund 2015 agreement with major powers, but still short of the 90 percent threshold needed for a nuclear warhead.